As a PC you're potentially a mover and shaker, not the best of the best of the best. The same goes for all the gangs, corporations etc. etc. in the game. The world is huge and the PCs are little guys trying to make a score, not monolithic figures who dominate their fields.
Like Vera just touched on, it's very easy for all the PC talent a PC would need to somehow end up at odds with them.
(Edited by Slither at 12:16 pm on 1/4/2020)